Why the Drugs Don’t Work and the Market Won’t Fix Them

Why the Drugs Don’t Work and the Market Won’t Fix Them

Why the Drugs Don’t Work and the Market Won’t Fix Them

This winter, like most winters, I’ve been ill. As an asthmatic, I’m susceptible to every respiratory bug going. With two kids in nursery, it’s pretty much guaranteed that every bug going will find its way to me. And so, for about the fourth year in a row, I’m on antibiotics.

I hope they work as well this time as they have in the past. But they might not. And it’s even less likely they will work in the future. Because some strains of Staphylococcus aureus, the bacterium infecting my lungs, are gathering resistance to antibiotics. Heard of MRSA? Well the ‘SA’ stands for Staphylococcus aureus.

Natural selection

The drugs we have for treating bacterial infections are becoming progressively less effective as new strains of the bacteria develop with better and broader resistance to the antibiotics we have. It’s a fascinating process that causes this: a kind of accelerated natural selection.

Some strains have always had a natural resistance to antibiotics. Sometimes a bacterium mutates, acquiring resistance. But in both cases these resistant bacteria have been dominated by the non-resistant strains being more numerous and widespread. Until we started killing those non-resistant strains with antibiotics, leaving the environment — human bodies — clear for the resistant strains to thrive.

Novelty value

Our solution to this in the past has always been to introduce new antibiotics. Ones to which the bacteria have not evolved resistance. This was always a fixed-term game but by minimising the use of these more powerful antibiotics to the cases where they were absolutely needed, we could extend their useful life. Now however there are so many cases where bacteria have proved to be resistant to first line treatment that the long term effectiveness of our second and third line treatments is under threat.

So, we have a massive pharmaceutical industry lining up the next round of big guns, right? Wrong.

As this chart from the research group Extending the Cure (which I picked up from this article in Wired) shows, the number of new antibiotics in development has fallen sharply.

Market forces

I always imagined that making and selling drugs was a pretty good business to be in. If your drug can cure someone’s sickness or even alleviate the symptoms, then they’re pretty motivated to pay for it. And there are a lot of people in the world suffering some pretty common complaints that you could alleviate. Surely the volumes of antibiotics used worldwide guarantee a pretty good return on researching new ones?
It seems not. One widely accepted reason for the dearth of new drugs is that antibiotics just aren’t profitable enough. As William Schaffner, chairman of preventative medicine centre at the Vanderbilt University Medical Centre in Nashville put it in an interview with ABCNews: “If you create a new drug to reduce cholesterol, people will be taking that drug every day for the rest of their lives. But you only take antibiotics for a week or maybe 10 days.” He likened it to selling a car that could only be driven if every other vehicle wasn’t working.

Now I don’t entirely buy this analogy: if you have a fairly fixed timetable within which the other cars are going to be off the road, surely there’s reason to invest today? But the drug companies know an awful lot more about profiting from drugs than I do. However important their work is to human wellbeing, they are companies and what they are there to do is make profit for their shareholders.

Alternative models

I have no issue with capitalism as such. It has done OK at getting us to the point we’re at today. But examples like this really point out its holes. When there are no economic incentives to create drugs that save lives and alleviate suffering, you know the system is a little bit broken.

Some have suggested creating incentives for the drug companies to go back to making new antibiotics. But when you have to twist a market to serve such noble ends, perhaps the solution lies elsewhere?

And this is where I get to the future aspect of this post. In the creation of drugs, as we increasingly will in other areas crucial to human life and happiness, I think we need an alternative to the market.

When the drugs don’t work, and the market won’t fix them, it’s time to think a little differently.

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This article is by Tom Cheesewright. This post forms part of the Future of Humanity series. For more posts on this subject, visit the Future of Humanity page.

Tom Cheesewright

https://tomcheesewright.com/futurist-speaker

Futurist speaker Tom Cheesewright is one of the UK's leading commentators on technology and tomorrow. Tom has worked with a huge range of organisations across a variety of markets, to help them to see a clear vision of tomorrow, share that vision and respond with agility. Tom draws on his experience to create original, compelling talks that are keyed to the experience of the audience but which surprise and shock with unexpected facts and examples.

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